Looking for a product boasting Minoxidil 8%, Dutasteride 0.3%, Spironolactone 0.075%, Tretinoin 0.01%, Ketoconazole 2%, and Hydrocortisone 1%? You're in luck. But before you jump on board, consider the following.

We strongly advise against using a product with such a blend for several reasons:

1. The Dutasteride concentration at 0.3% is excessively high. For comparison, the commonly used topical finasteride concentration stands at 0.1% (equivalent to 1mg finasteride per ml). Dutasteride is a more potent DHT blocker with a longer half-life than finasteride. 1.0ml of 0.3% dutasteride solution contains 3mg of dutasteride, a dosage far beyond the needs of 99% of users.

3. The addition of 0.075% spironolactone to the solution is ill-advised. Spironolactone isn't stable in a solution with minoxidil and gives off a potent, unpleasant odor, making the solution user-unfriendly.

3. Ketoconazole 2%: While FDA-approved for use in shampoos that briefly contact the scalp, there's no evidence demonstrating its benefits outweigh the risks when used long-term in leave-in solutions. Potential side effects include scalp irritation, dryness, and hair breakage issues.

4. Hydrocortisone 1%: While added to soothe the scalp and reduce irritation and inflammation, it's crucial to note that hydrocortisone is a hormone. Long-term safety studies for its use at 1% are lacking. Prolonged application over large areas of the body or under occlusive dressings can result in skin thinning and increase susceptibility to bruising. Furthermore, systemic absorption can lead to adverse effects like adrenal suppression, Cushing's syndrome, or hypothalamic-pituitary-adrenal (HPA) axis suppression.

For those reasons, we strongly recommend you consider some other solutions such as Maxogen-X and FinoDuta that have a more optimized list of ingredients and concentrations.