This is a looooong article about the world’s second best selling hair loss treatment product Finasteride. For regular customers, it will be more than enough to just read the 16 frequently asked questions about finasteride. If you want to be an expert on finasteride, you can read the second part, which is our professional finasteride review.
1. What is Finasteride?
Finasteride is one of the two FDA approved products for hair loss treatment, the other being minoxidil. Interestingly, both finasteride and minoxidil were discovered to have hair growth effect as side effects. Minoxidil was found to grow more hair in those people who took in as an antihypertensive vasodilator medication; while Finasteride (brand name Propecia) was found to halt hair loss and even reverse hair loss when it was taken to treat benign prostatic hyperplasia.
2. How does finasteride work?
Finasteride inhibits expression of the enzyme, 5-alpha reductase, which regulates production of dihydrotestosterone (DHT). By lowering DHT levels in the scalp, it reduces DHT’s harmful effect on hair follicles. Finasteride decreases DHT concentrations in the serum and the scalp by up to 70 and 60%, respectively. Male pattern hair loss, or androgenetic alopecia, is an androgen-dependent disorder. In genetically susceptible men, dihydrotestosterone (DHT), a potent metabolite of the male androgen testosterone, contributes to male pattern hair loss. The conversion of testosterone to DHT is regulated by the enzyme 5-alpha reductase.
3. How does finasteride affect the body’s hormonal / endocrine system?
Finasteride (Propecia® and others) is a specific type II 5-alpha reductase inhibitor (on the contrary, Azelaic acid is a non-specific 5-alpha reductase). That is, it inhibits the enzyme responsible for regulating conversion of testosterone to dihydrotestosterone (DHT). By reducing DHT levels in the scalp, the drug decreases DHT’s effects on the hair follicles, reversing the process of hair loss.
4. Is topical finasteride as effective as Finasteride pill?
Finasteride is initially approved as oral pill to be taken once a day. The usual dose is 1mg daily taken with or without food, at any time during the day. A topical formulation of finasteride has been approved in India and has been found to be as effective as oral finasteride.
5. Why women should not use finasteride?
Finasteride is not indicated for use in women with hair loss (female pattern hair loss). Finasteride is contraindicated in women when they are or may potentially be pregnant, because it may cause abnormalities of the external genitalia of a male fetus (Pregnancy Category X, i.e., drugs that have such a high risk of causing permanent damage to the fetus that they should not be used in pregnancy or when there is a possibility of pregnancy.)
6. How effective is finasteride?
The data are from three large, multicentre, placebo-controlled studies of 1,879 men with mild-to-moderate, but not complete, male pattern hair loss. The men received either oral finasteride once daily or placebo for one year. The endpoints for the studies were objective hair counts taken from a 1-inch diameter circular area, and subjective assessments of improvement by patients, investigators, and an independent panel of dermatology experts who evaluated pre- and post-treatment photographs.
The trials showed that finasteride can prevent hair loss in men with mild-to-moderate male pattern hair loss. In two of the clinical studies involving men with mild-to-moderate male pattern hair loss, 86% of men treated with finasteride maintained or showed an increase in the amount of their hair based on hair counts during the course of the studies. Only 14% of men treated with finasteride had further hair loss after 12 months of treatment, compared with 58% of placebo patients.
On-going studies have demonstrated that finasteride halts hair loss or regrows hair in 9 out of 10 men taking it long term every day.
7. Are some patients more likely to respond to finasteride than others?
It is difficult to predict which patients will respond and to what extent. Patients studied in clinical trials had mild-to-moderate, but not complete, hair loss, and ranged in age from 18 to 41.
8. How long do I need to take finasteride to see any result?
Daily use for three months or more may be necessary before a patient will notice prevention of further hair loss or increased hair growth.
9. Can I stop use finasteride once I have grown enough hair?
Daily use of finasteride for three months or more may be necessary before a patient will notice prevention of further hair loss or increased hair growth. There are no controlled clinical data on treatment for longer than 12 months. It probably will be necessary to continue treatment indefinitely to maintain the benefits.
10. What happens if you stop taking finasteride?
If a patient stops taking finasteride, DHT levels will rise again in the scalp, and it is likely that hair loss will resume.
11. Will I grow more hair on other part of my body?
Finasteride is a specific inhibitor of type II 5-alpha reductase, which is found primarily in scalp hair follicles. In clinical trials, there was no reported effect on hair on the other parts of the body.
12. What are the side effects of finasteride?